The 36-year-old tennis star, who reached the Roland Garros semi-finals in 2017, has only made one appearance at the tournament since then.
Last month, Murray expressed his desire to have another opportunity to play at the Grand Slam while he is in good physical condition.
Although he won the Challenger Tour d’Aix-en-Provence title earlier this month, the three-time Grand Slam champion has had early exits at recent tournaments such as Monte Carlo, Madrid, Rome and Bordeaux. .
Murray’s decision to withdraw from the French Open marks a setback in his ongoing journey to regain his best form.
The Scot has opted to skip tournaments during the clay season in the past to focus on the grass swing towards Wimbledon.
In February, he said Wimbledon offered him the best chance of going far in a Grand Slam.
The French Open runs from May 28 to June 11. Holder Rafael Nadal, who has won the French Open a record 14 times, also withdrew from the tournament after failing to return to full fitness with a hip injury.
Australian Nick Kyrgios and Italian Matteo Berrettini will also miss the tournament.
(With Reuters entries)