Williams will compete in women’s singles, according to an announcement from Wimbledon on Tuesday.
The social media post showed her standing on a grass court in white sneakers.
Williams has not played competitively since injury forced her to withdraw in a first-round match at Wimbledon last year.
The 23-time major champion last reached the Wimbledon final in 2019 where she lost to Simona Halep, who now works with former Williams coach Patrick Mouratoglou.
Williams will first return to the court in Eastbourne next week for the LTA’s Rothesay International, partnering Tunisia’s world No. 4 Ons Jabeur for the doubles event, in what will be her first appearance in a tournament in nearly a year, depending on the tournament.
Widely regarded as the GOAT of women’s tennis, 23-time Grand Slam champion Serena Williams says she is still aiming to break Margaret Court’s record of 24.
“I should have been 30 or 32 (Grand Slam singles titles),” Williams told CNN’s Christiane Amanpour earlier this year.
“I should have had it (the record), really, I had a lot of chances to have it. But I’m not giving up.”
Williams was forced to miss January’s Australian Open on the advice of her medical team, announcing in December that she was not “where I physically need to be to compete”.
Wimbledon is scheduled for June 27-July 10 at the All England Lawn Tennis & Croquet Club.
Jill Martin, Alicia Lloyd and Christiane Amanpour contributed reporting.