With the massive win, the Pelicans also completed a four-game season series sweep.
Brandon Ingram scored 32 points to lead five New Orleans players in double digits for the host Pelicans.
Jonas Valanciunas added 19 points and 15 rebounds, Trey Murphy III had 17, CJ McCollum had 15 and former Spur Josh Richardson had 10.
Ingram made all of his 10 free throws and 10 of 16 field goal attempts as New Orleans shot 55.6 percent (45 of 81) from the floor.
Sandro Mamukelashvili scored 20 points, former Pelican Devonte’ Graham and Tre Jones added 15 each and Keita Bates-Diop had 12. Spurs (19-53) played without top scorer Keldon Johnson (neck), second-leading scorer Devin Vassell (knee) and leading rebounder Zach Collins (resting).
The Pelicans scored the first six points of the third quarter to take a 70-39 lead.
The Spurs cut the deficit to 22 points twice in the period before New Orleans rebuilt it to 31 and held a 91-65 lead at the end of the quarter.
Spurs held on to their last lead at 14-13 after Mamukelashvili’s 3-pointer with 6:58 left in the first quarter. It was also their last basket of the period.
Ingram and McCollum scored four runs apiece on a 10-0 Pelicans run before Graham made two free throws to end San Antonio’s 5 1/2 minute drought.
Four free throws from Ingram wrapped up the quarter and left New Orleans with a 27-16 lead at the end of the period.
Valanciunas had four points as the Pelicans started the second quarter with a 10-2 run that gave them a 19-point cushion.
Jones scored seven points to help Spurs close on 12 before Richardson scored two 3-pointers to help New Orleans open a 22-point lead.
Graham converted a three-point play and made a 3-pointer to help San Antonio within 15 before the Pelicans scored the final 10 points and extended the lead to 64-39 at halftime.
(With contributions from Reuters)
